Pathogens rely on virulence factors to facilitate infection and colonisation in plants, animals and humans.

This research aims at elucidating the structural details and enzyme mechanism of the two major glycosylating virulence factors, toxin A and toxin B, from Clostridium difficile as well as the less well known lymphostatin from enteropathogenic and enterohemorrhagic Escherichia coli strains.

This work will enhance our understanding of the enzyme mechanism of this medically important class of enzymes. It will also facilitate the development of active-site inhibitors, not only as tools to study GT reaction mechanisms, but also for the development of anti-virulence compounds that may lead to novel therapeutics.

Last revised 19 February 2018


René Jørgensen
Tel: +45 3268 3895